Hi Lukaszs,
Unlike Ramon replied, the behavior in ACS (standard) is the same as ACC (classic), it means the blacklist is done at profile record level, not email:
Adobe Campaign Help | About opt-in and opt-out in Campaign
So for instance, exclude rules (typology or delivery) is done per contact, not email shared between contact.
The only location where is the action is common to all contacts/email based is nms:address (quarantine management).
Regards
J-Serge