@MYSTERIOUSMAN ,
You can use Journey Orchestration (profile orchestration) with the updated profile node with flag segments that are pushed to the trade desk, Facebook, google.
With this, you end up having lot of useless (operative) segments in their instance for each use case. It works, but not really clean.
However, in this use case, it is possible to activate that segment (people who did not interact with any of the messages in that journey) for the destination and add a “segment qualification” step. After that, add a wait step and then add another “segment qualification” for people who did not interacted with the ads.