You would have a couple of options here, in my opinion.
The quickest & dirtiest, in my opinion, is to have the labels of those fields be what they are now, but the values be their numbers, so for example, your LOE score would have human text in the label fields, but then in the value fields it would be 1 - 5, and rush would be 1 (default) or 2 (Yes). Then you could just built your math equation that way.
The other way, which is better, IMO (I don't like having different values/labels, but that's just me), is the exact reason that I made a request to Workfront to add a switch statement, but for now, for every value, you would have to build an IF table to convert the selections to numbers, and then do your math. So for example,
IF({LOE Score}="Text1", 1,IF({LOE Score}="Text2", 2,IF({LOE Score}="Text3",3,IF({"LOE Score}="Text4",4,IF({LOE Score}="Text5",5,0)))))
multiplied by
IF({Rush}="Selected",2,1)
For however many variables you have.