Going thru notifications and emails is really not working for my group of collaborators.
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Probably the only users with My Updates as a page are the reviewer/requestor folks. I would start by giving them Home for the top half of the page. Then the current workaround for the rest of the page is putting the notifications page on a dashboard (https://yourinstance.my.workfront.com/notifications). You could optionally create a report that mirrors the top half of that page but I'd advise against it, since you get a lot of users requesting that you mirror buttons so that they can get the same functionality.
We had a question somewhat like this from some of our new users. I created a report on a dashboard that sorts their notifications in date order so they can go through them easier.