You should be able to - set up an ODBC data source pointing to the DB2 database, and then connect to it by adding an OLEDB Database connection in Designer.
When you select OLEDB, and hit Next, then hit Build, you'll get a list of OLE DB providers; one of those providers is a bridge to an ODBC data source ("Microsoft OLE DB Provider for ODBC Drivers").
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SteveX
Adobe Systems