Custom parameters vs Visitor Profile




I'm reading help documentation regarding creating audiences and am a bit confused:

If I want to target mbox profile attributes (which I think = profile parameters?), should I choose Custom or Visitor Profile when adding a rule? What's the difference between them when it comes to target

In Visitor Profile doc, it says You can target custom profile parameters and profile script (user.parameters) but I see no problem doing it in Custom category?

Thank you!

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Thank you Eric and Shruthi Naomi​ - so just to confirm, I can choose to use Customer for profile attributes (profile.something) then?! I thought that I couldn't hence raised this question...Thanks