Hi Nate,
We implemented in 2008 at a small community hospital in northern California. I would say that, given the (sometimes challenging) nature of healthcare + technology + workflow + workarounds, it is best to keep your initial goals small in scope, attainable, and clearly defined and communicated. Take baby steps, because it takes time to build momentum and change culture. Real, dramatic change isn't measured in months, but rather in years, at least that's been my experience. So; manage expectations, and build on small successes at first, widening your scope as your teams gain experience and the culture slowly changes. It helps to have an excellent team of crack project managers to help drive the change, along with a tool like Workfront which provides facile transparency and reports/dashboard measurements.