This was the response from Adobe Support and Adobe Build Engineers

To put this into perspective:- We are creating packages with content and replicating it from author to publish.- We are not using activation processWhen content is activated, the dispatcher invalidates correctly.When content is replicated in a package, it does not invalidate correctly.

I am experiencing an issue when replicating a package from Author to Publish.When content is package and replicated, items in \Content\Dam are not invalidated on the dispatcher and a manual cache clear needs to be performed. (Specifically PDF files)I contacted Adobe about this, and their response is...

Hi Everyone,My name is John Pedrick and I am a System Engineer working with AEM at Novo Nordisk. I have been a system engineer, mostly on the operation side, for several years now.I look forward to meeting everyone on here.Thank youJohn Pedrick