I completely agree...does anyone know if this been addressed? I found some suggestions from last decade. And the decade before. If I could change ONE thing in WF, this would be it.

I agree! I am a new user of Workfront and it always surprises me that I can't do what I want when this happens, and then I realize I have to go x out the profile pop-up. Usually it is me I have accidentally hovered over. I don't need to know any more about me.