Hi Raaghu,
Yes, use update activity with:
Dimension to update: Address (nms)
Operation type: delete
But please note that normally, new mailboxes full are considered as soft bounces during 5 days (by default) of a delivery sending attempts, then considered as hard bounces.
So if you delete them you could have some deliverability issues (being considered as spammer by ESP, Email Service Providers). So you need carefully exclude them from targetting, because the typology rule won't exclude them automatically from deliveries.
To my mind it is a very risky approach.
Regards
J-Serge