The Home and End keyboard keys do not work properly in the search box in the New Experience. In the classic interface, you can use those keys to move the keyboard cursor inside the search box. In the New Experience, the Home and End keys actually navigate the results preview drop-down list. It is less useful and less intuitive now, because the Home and End keys behave differently in the search box compared to any other field in Workfront.
For comparison, try using the search box on the home page of Google. You can use the up/down arrow keys to navigate the results preview drop-down list, but the home/end keys move the keyboard cursor to the front/end of the search text. This is the standard behavior for most applications, and it would improve the user experience in Workfront if it was the same.