Hi @andyshreve ,
1) EDS doesn't have this feature out of the box. However, there is an example how you can use SCSS for your project: https://github.com/sachioross/helix-project-boilerplate-sass . Based on this example you can implement minifying.
Note: most likely you will need to keep 2 version of files in repo: {resource}.scss, {resource}.min.css, {resource}.js, {resource}.min.js
2) EDS doesn't have this feature out of the box and it's not needed, because JS/CSS are returned with ETag and Last-Modified header that solves problem with cache as well. I'd not suggest applying long term caching for your JS/CSS with additional headers feature.
Best regards,
Kostiantyn Diachenko.