I checked with our engineering team, and error 333 is related to the number of metrics involved in a report. To resolve this, you will want to limit the number of items you're using; for example, find ways to combine the segments and limit the number of simultaneous metrics the ad hoc report is running.
Data Warehouse is a tool that is much better equipped to handle requests with large numbers of metrics and breakdowns. I would recommend considering using that tool if you're not able to get what you need from Ad Hoc Analysis.