There are many places where you can generate your PDF from the editor in 4.2, like from the icon in the left corner of the screen, or the Generate Output menu option from the Map panel that opens when you double-click a map. Both of these have the Folder Profile's list of presets available for generation.
How do you set up the presets for the "Quick Generate" menu item that is available from the (...) beside a map in the repository? It expands to "Select Presets" and if that is selected, it says 'No presets available". It has the same icon as the other generation items, but has not automatically set up the presets.