Facing error while login to Adobe Campaign Classic console

IOB-090007 Network error (connect(), errno=10061: no connection could be made because the target machine actively refused it.)
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INT-150003 Cannot open an HTTP connection with server 'jp-tyo-cmpprd03.ap.elcompanies.net'.
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Hi All, we are facing above error whiile login to  Adobe Campaign Classic console

Please help what we can do to fix this error

IOB-090007 Network error (connect(), errno=10061: no connection could be made because the target machine actively refused it.)
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INT-150003 Cannot open an HTTP connection with server 'jp-tyo-cmpprd03.ap.elcompanies.net'.
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