Are AEM OOTB Libraries Compatible with GCC?

Hey there, I have been playing around with the gcc minifier in the Adobe Granite HTML Library Manager settings and it looks great and a big improvement over YUI. One question though. Is it safe to use across the board (i.e. set in OSGi config?) or is it a better idea to apply gcc minification to client libraries I have inserted (i.e. by using the jsProcessor property on the cq:ClientLibraryFolder node).

Thanks!