Is it possible the use of "equals any of" is the culprit? I believe the delimiter there is the space.... so you are really saying:
Any of "422" or "interacted" or "on" or "the" or "homepage"
Meaning that ANY "Target Activity" that contains ANY of those words is included.....
Why not just use:
Target Activity equals "422 - interacted on the homepage"
AND
Target Activity equals "375 - interacted with at product details page"