Need to change Time Zone for Live Report Suite

Changing the time zone for a live report suite creates either a spike or gap in report data. To minimize the impact, Adobe recommends changing time zones during non-peak hours to avoid skewing data.

https://docs.adobe.com/content/help/en/analytics/admin/admin-tools/general-acct-settings-admin.html

Depending on how new the report suite is, and if a lot has already been built upon it - you could chose to instead leverage a virtual report suite with a different time zone.

You need to check with your business people and find out nonbusiness hours, they are the best people to answer your question based on that calculate and decide the Eastern time zone.

You can also check the last few week's reports and check at what time you get low visits. based on that you can make a decision.

Before that, if you stage report suite, just go and change and check how it behaves to get more idea on it before going to prod report suite.