Follow up email exclusion

Hello,

I'm looking to do a follow up email which I understand the steps to do that by changing the resource from profile to the email that I want to follow up. However, I'd like to exclude a certain population from the final send. The group that I'd like to exclude is a query that targets data from the profile.

How would I go about doing this?

I set up the workflow with the query that uses the email as the resource, and then set up another query to get the population for exclusion - but obviously if I leave it the way it is, I'm then targeting two different event types, and get the error: The document types of inbound events ('head:EVTwelcome' and 'head:profile') are incompatible. Unable to perform the operation.

I need to keep the events to target the email in order to do a follow up email, so essentially, how would I go about excluding the second query's population from the end target?

Thanks