Single or Multiple Destinations for a DSP?

Hello,

I was wondering what the best way to send segments to a DSP is? Should we create a single destination specific to the DSP or should we create uniques destinations for that DSP specifically for a single segment?

For example, the DSP is AppNexus and we first want to send them a suppression segment but know that down the line we'll be sending other segments that contain a lookalike model, or perhaps a retargeting segment. Do I need three destinations or only one? I just want to know the best practice to ensure things are as clean as possible.

Also, in this instance I'd want a S2S destination correct?

Glenn Bourque