RTP Segmentation - exclude ISP or no?

I created a segment for our target ABM industries; for this example, we'll use "Financial Services"

When I create the segment, should I exclude ISPs as a secondary filter? My thought is that someone could be identified as Financial Services, but then possibly work from home or a coffee shop (on an ISP) and then be dq'd from my campaign? ...or maybe I don't fully understand how it works.

Input? Thoughts?