Issues with Changes Not Saving

For the past week I have been experiencing issues with Marketo not saving changes I am making to emails, campaigns, and files. I have replaced (even deleted and re-uploaded) files and the old versions will still populate. I have made changes to alert email recipients and the old email addresses will be there when I go to check the program is running correctly. I have also made design changes to emails and updated button links but when I go to test the email the changes are not there. I have been approving and saving all changes. I have tried not only clearing my cache but have also tried different browsers, different user logins, and restarting my computer but it doesn't seem to make a difference. Does anyone know why I would be experiencing these issues or how I can prevent this issue in the future. It is crucial that the changes I am making be implemented immediately and not default back.