Taking Marketo's Email Performance report and then doing some work in Excel is going to be the easiest (and relatively unpainful, actually).
Here are some steps:
Create an Email Performance report in Analytics.
Go to "Setup" and edit the time frame and emails appropriately (probably "all time" and every email in this case).
Run the report
Export to CSV
There are two ways to get the number you're looking for, and I'd grab both and see how different they are:
Average of averages: =(SUM(I:I)) Take the average of "% Opened" column. This is an average of averages, which isn't necessarily a good thing in a pure math sense, but if you want to weight small-number recipients more, it can be directionally helpful to see if you should segment some more or find another proxy.
Total number average: =(SUM(B:B)/SUM(H:H)) Take the total "Sent" and divide by total "Opened." This is going to be skewed pretty heavily if you have lots of operational fulfillment emails, so take it with a grain of salt. I usually group emails into like-categories, such as Lead Nurture emails, and then separate things like fulfillment emails.
I agree with Edward. Although Marketo can show you averages, I like manipulating data in Excel to further drill out results and make them easier to mail out.
Without disagreeing with Edward and Kristen (especially about the significance of this overall open/sent number) I would say if you're only doing this one task, leaving the browser for Excel is unnecessarily cumbersome.
For our users we've put together some JS snippets that they have bookmarked in their browser to do some quick additional calculations/appraisals. Here's the script for the number you're talking about. Of course this wouldn't be copy-and-pasted every time but you it's just a link on your bookmarks bar like Calc Total Open/Sent.
javascript:var SENT_CLASS='x-grid3-col-Sent',OPENED_CLASS='x-grid3-col-Opened',PARENT_CLASS='x-grid3-summary-table'; var s=document.querySelector('.'+PARENT_CLASS+' .'+SENT_CLASS).textContent.split(',').join(''); var o=document.querySelector('.'+PARENT_CLASS+' .'+OPENED_CLASS).textContent.split(',').join(''); var totalos = parseInt(+o/+s*100)/100; alert( 'Total Open/Sent = '+o+'/'+s+' = '+totalos );