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What OS are you running it on?  I've had issues with running Adobe LiveCycle and Designer in Windows Vista.  There is funky Vista security on the Program Files folder.  If you are running Vista, try to make sure Designer is installed into C:\Adobe\... instead of C:\...\ProgramFiles\Adobe (which is generally the default).

Hope this helps!

Ryan D. Lunka

Cardinal Solutions Group

rlunka@cardinalsolutions.com