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Hi @NayanMistry 

Sorry for the delay, one of the best way to increase operational efficiency is to build re-usable elements and pre-defined filters are one of them, you can use pre-defined filters in typology rules. Saying that, typology rules works on a slightly different way in a sense that a criteria in a typology rule needs to produce the list of recipients to exclude while in a workflow you would need pre-defined filters to get a list of recipients to include. 

So you could do things in 2 ways:

  1. 2 set of pre-defined filters: one that provides the list to exclude (used in Typology Rules) and one that provides the list to include (used in workflow), the rules of these 2 pre-dfeind filters are opposite. 
  2. Create a single pre-defined filter that provides the list to exclude (used in Typology Rules) and in a workflow you would use the Exclusion activity joining the main target with the list of recipients to exclude

In the past, I went option 1 to keep workflow structure simpler than solution 2. Option 1 is a slight overheard for maintenance but it's not complicated to maintain.

But yes you should use pre-defined filters in typology rules too.

Hope this helps.

Thanks

Denis