After several attempts, I'm finding that on some Audiences, I'm unable to edit. In other words, clicking on the pencil icon in the Audience List does nothing.
Is there something within the Audience itself that would cause this? I even thought perhaps having the Activity using the desired audience open (edit activity) might be the cause...not the case. Additionally, this audience is only being used on one Activity.
In general, clearing cache and cookies is obviously not an ideal pre-requisite to having updated functionality work. I will connect with Engineering to see if there is anything we could do differently in the future to avoid such situations. Thank you for the feedback bkmills1 and russpainter!