Yes -- I've been working LC Designer 11 [LCES 4] on Win10 for greater than 1 month with no issues whatsoever
HARDWARE: VAIO F137
SOFTWARE: Adobe Acrobat X Pro + LC Designer 11
I'm running LC 11.0.1 on Win 10. Preview PDF is not working for me, but everything seems to be very smooth. Create and save a file in LC, leave it open in LC. Open same file in Pro XI11.0.12, see where it lacking, correct in LC. Cant save in LC until XI pro instance is closed. Working great for me!