To me, the answer would vary based on your requirements. Couple of generic points to consider:
1) Security aspects - Is the content supposed to be secure/behind authentication/tokenized?
2) CORS use cases, if any
3) Size of requests, # of requests, size of headers - should you consider cookieless domain for any use case?
4) Existing architecture/setup
5) SEO requirements
6) Caching requirements
7) Flushing requirements, frequency of rollout/changes
etc.