I'm facing this error "HTTP Error 404.0 - Not Found The resource you are looking for has been removed, had its name changed, or is temporarily unavailable." when I setup dispatcher to the IIS. I tried all the steps mentioned in Adobe documentation Installing Dispatcher
I am getting the same issue and I performed all the action as discussed above ...what small or big thing I am missing here please let me know . even dispatcher.log file is not getting generated in my case
Issue related to "Not Found" error has been resolved. Solution for me was also applying steps 6,7,8,9 from "Integrating the Dispatcher ISAPI Module - IIS 8.5 and 10" section for IIS 10 (Installing Dispatcher).
Now I'm facing another issue with cache permissions.
I always see the following message: "Unable to create parent directory C:\inetpub\wwwroot\content\mysite\en: Permission denied".