Can you tell us what you've tried so far? What platforms you have tried to preview it from (device? browser?)? What network speeds are you experiencing? It is a large publication? I assume this worked fine up until now? What was changed/updated in the publication before this started happening? What is the exact message that it is presenting you?
If you call support and get a ticket open, they'll get publication information from you and a more in depth investigation could happen.