ACC does not rely on SMB that I know of, obviously if you would like a more official answer you need to raise a ticket to Adobe TechOps.
Also, if there was any ACC feature making use of SMB; it would've been updated/patched long ago and mentioned in the release notes as SMBv1 was deprecated in 2013.
https://experienceleague.adobe.com/docs/campaign-classic/using/release-notes/latest-release.html?lan...
For peace of mind, I suggest to start with disabling it on your staging environments.