I'm considering your query is specific to AMO Display. If yes, please refer to the below and try it out.
From 'Domain Referral Report' under Advanced Reports drop down option, you can refer to all the domains & sites which are performing or non performing ones for respective campaigns/portfolios.
You can utilize your money by optimizing campaigns by including and excluding the respective domains at Ad strategy level. You can even manage your bids for performing & non performing ones. Notably, this will help to improve the campaign performance and get better ROI for your campaigns.