Hi Luis,
I don't think there is any facility to upload URLs to directly edit or update segments, but there may be some other ways to acheive what you need.
Are there some other commonalities in your urls that you could segment on instead? For example, if you are trying to categorise your URLs by product group, and they share a common structure (www.example.com/snow-gear/jackets/red-fluffy-medium.html, perhaps you could use a CONTAINS condition could for "/snow-gear/", or "/jackets"?
If this isn't viable, another solution might be to create SAINT classifications to group your URLs, and then you can regularly upload your excel classification file, and create segments based off the groupings.
